Banca de DEFESA: ELENARA BOTELHO ARAUJO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ELENARA BOTELHO ARAUJO
DATE: 27/01/2022
TIME: 08:30
LOCAL: Setor de reprodução animal/ISPA/UFRA
TITLE:

 MicroRNAs expression  in female dog mammary neoplasms

KEY WORDS:

Female dog, mammary neoplasms, microRNAs

PAGES: 22
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Reprodução Animal
SPECIALTY: Fisiopatologia da Reprodução Animal
SUMMARY:

Similarities in predictive factors of breast neoplasms between canine and human species ave been demonstrated, promoting to an experimental model for the study of female dog cancer in women. Given the high incidence of this pathology in both species, the deepening of the study of its etiology, treatment and evolutionary prognosis is important, especially when addressing the genetic character of female dog cancer, whose factors are still somewhat obscure. Research has been relating changes in gene expressions with the formation of tumor cells, promoting a significant increase in studies of genetic diagnoses, which becomes increasingly in-depth and specific, involving analyses of the expression of microRNAs, which have been shown to participate in the regulation of the mechanisms involved in tumor development, through their role in the post-transcriptional regulation of proteins, leading to degradation or inhibition of the translation of the target messenger RNA. The present study aims to analyze 15 samples of bitches mammary tissue affected or not by  neoplasms of female dogs with and without history of exogenous hormonal administration, in order to detect the expression of possible microRNAs involved in the formation of breast neoplasms in, aiming to improve studies for a possible preventive examination for this pathology.

BANKING MEMBERS:
Interno - 1556914 - EDNALDO DA SILVA FILHO
Interno - 388431 - HAROLDO FRANCISCO LOBATO RIBEIRO
Externa à Instituição - SIMONE DO SOCORRO DAMASCENO SANTOS - UFPA
Externo à Instituição - WILLIAM GOMES VALE - UECE