Banca de DEFESA: THYAGO HABNER DE SOUZA PEREIRA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : THYAGO HABNER DE SOUZA PEREIRA
DATE: 29/08/2023
TIME: 14:00
LOCAL: Auditório da Universidade Federal do Norte do Tocantins
TITLE:

HISTOLOGICAL CHARACTERIZATION OF ENDOMETRIAL COLLAGEN IN THE REPRODUCTIVE CYCLE OF Lagothrix poeppigii AND Cacajao calvus


KEY WORDS:

collagen type I; endometrium; extracellular matrix; neotropical primates.


PAGES: 51
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Reprodução Animal
SUMMARY:
Understanding reproductive physiology is essential to improve conservation biology and develop biotechniques for reproductive management of endangered Neotropical primates. Thus, morphophysiological studies are carried out to elucidate many aspects of the estrous and menstrual reproductive cycle of these species. In this context, the aim was to morphologically characterize changes in the endometrium of woolly monkeys (Lagothrix poeppigii) and uacaris (Cacajao calvus) throughout the reproductive cycle, with emphasis on the expression of endometrial collagen. Initially, a narrative review of the literature was carried out based on bibliographic surveys on the reproductive biology of the genera Lagothrix and Cacajao, highlighting characteristics of the reproductive cycle, pregnancy and morphophysiology of the female genital tract. Then, the evaluation of uterine fragments of the species L. poeppigii (n=6) and C. calvus (n=6) was carried out for histological characterization by colors in hematoxylin-eosin and Masson's trichrome, and quantification of collagen by the Picrossirius technique Red. A narrative review allowed a gathering of data on the reproductive biology of both genera describing the slow reproductive activity, the macro and microscopic aspects of the female genital organs and information about the reproductive cycle. In the histological characterization, it was possible to identify the accumulation of hemosiderin in the subepithelial region in C. calvus, indicating the possibility of menstrual activity. However, except for L. poeppigii, there were no histological signs of menstruation. With the collagen ratio, a difference in endometrial expression was observed throughout the reproductive cycle of C. calvus (p < 0.001) and L. poeppigii (p = 0.03). Females of C. calvus in the early, late proliferative and secretory phases showed greater collagen expression than pregnant women (p = 0.002, 0.02 and 0.001, respectively). In L. poeppigii, a higher expression was observed only in the secretory phase in relation to the gestational period (p = 0.04). Both species experienced increased collagen expression in the basal endometrial region compared to the functional layer, with mainly type I collagen and lower expression of type III collagen being observed. The histological characterization from the Picrossirius Red technique allowed the evaluation of the predominant types of collagens and the quantification of its expression in the endometrial connective tissue, being relevant for future studies on the expression of matrix metalloproteinases through immunohistochemistry. Understanding the mechanisms of extracellular matrix remodeling in the reproductive cycles of neotropical primate species yields additional information on the reproductive physiology and menstrual markers of both species.

BANKING MEMBERS:
Presidente - 1305300 - FREDERICO OZANAN BARROS MONTEIRO
Externa à Instituição - FRANCISCA ELDA FERREIRA DIAS - UFT
Externo à Instituição - FRANCISCO ANTÔNIO FELIX XAVIER JÚNIOR - UECE
Externa à Instituição - HELCILEIA DIAS SANTOS - UFT
Externa à Instituição - JANAINA SERRA AZUL MONTEIRO EVANGELISTA - UECE
Externo à Instituição - SANDRO ESTEVAN MORON - UFT
Externa à Instituição - GAYCIANE BEZERRA DE MORAIS - UECE
Notícia cadastrada em: 24/08/2023 15:58
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