CYTOGENOMIC ANALYSIS OF CANINE MELANOMA.
Malignant Neoplasm; Dog; Chromosome; Karyotype; Expression microarray.
Melanoma is a highly heterogeneous cancer of melanin-producing dendritic cells. In dogs, it is responsible for 7% of all malignant neoplasms and the place of greatest occurrence is in the oral cavity. They mainly affect older dogs and those that have dark pigmentation on the skin and mucous membranes. The prognosis is generally considered unfavorable, and the diagnosis is made through the association of macroscopic characteristics, and cytopathological, histopathological and immunohistochemical tests. Although there is treatment, they are still not as efficient.Therefore, the use of cytogenetics has shown to be promising, as it allows for the correlation between the patient's clinical condition and the chromosomal alterations found.