Banca de QUALIFICAÇÃO: BIANCA SOUZA DE AMORIM

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: BIANCA SOUZA DE AMORIM
DATA: 14/12/2017
HORA: 09:00
LOCAL: Sala de reunioes do PPGSPAA
TÍTULO:

Effect of serum starvation and down-regulation of CD146 protein-expression on the cellular life cycle of oral canine melanoma cells

PALAVRAS-CHAVES:

Media conditions; Cluster of differentiation 146; Melanoma cells life cycle.

PÁGINAS: 21
GRANDE ÁREA: Ciências Agrárias
ÁREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
ESPECIALIDADE: Clínica Veterinária
RESUMO:

 

The oral cavity is place of 6% of all tumors in dogs, being the fifth most important localization of neoplasms in this specie. Melanoma is a type of cancer that originates from melanocytes and its establishment involves several stages, until the formation of an invasive and metastatic tumor. The exact molecular mechanisms of the dysregulation in melanoma are yet unknown. Many studies have advanced our knowledge towards understanding the multiple roles of CD146 in biology and pathology and have pointed to the significance of CD146 as a potential diagnostic marker for certain lesions including melanomas. In the present study, we used different kinds of serum starved cells to analyze CD146 protein-expression in oral canine melanoma, expecting that antibodies to CD146 inhibit tumor growth and metastasis. Through the analysis of cellular life cycle of melanoma, it could be possible to evaluate the best time point to use CD146 in dogs to prevent possible metastasis.

 

MEMBROS DA BANCA:
Presidente - 1449265 - ANDRE MARCELO CONCEICAO MENESES
Interno - 1733442 - ANA RITA DE LIMA
Externo ao Programa - 2494981 - ADRIANA MACIEL DE CASTRO CARDOSO
Externo à Instituição - BARBARA PRATSCHER - NENHUMA
Externo à Instituição - SABINE BRANDT - NENHUMA