Banca de DEFESA: GESSIANE PEREIRA DA SILVA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : GESSIANE PEREIRA DA SILVA
DATE: 07/08/2023
TIME: 14:00
LOCAL: Auditório do Centro Nacional de Primatas
TITLE:

BIOMEDICAL IMPORTANCE AND BIOMARKERS OF HEALTH AND SENESCENCE IN THREE PLATYRHINE SPECIES

KEY WORDS:

Comparative morphophysiology; welfare in wild animals; adrenal steroids; animal health.

PAGES: 75
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Reprodução Animal
SPECIALTY: Ginecologia e Andrologia Animal
SUMMARY:

Non-human primates (NHPs) make up a very varied group and have many behavioral and physiological similarities with humans. For this reason, they are excellent comparative models for biomedical, evolutionary, and aging studies. Thus, it is essential to monitor the health of PNH through health and senescence biomarkers, which include routine tests such as blood count, serum biochemistry, hormone levels, and imaging tests. The main hormone used to assess stress and well-being is glucocorticoids (GC), but attempts have been made to associate GC with other markers, such as dehydroepiandrosterone sulfate (DHEAS), for a more accurate assessment of the condition of these animals. Thus, Chapter 1 is a literature review regarding the use of the squirrel monkey (genus Saimiri) as an experimental model for studies of pelvic disorders in women, discussing the main similarities and differences found. Chapter 2 deals with the validation of the DHEAS assay in howler monkeys (Alouatta caraya), owl monkeys (Aotus azarai), and capuchin monkeys (Sapajus apella), in feces and blood samples. Chapter 3 consists of renal evaluation using ultrasound and laboratory tests in howler monkeys (n = 20) and capuchin monkeys (n = 21), considering the effects of sex and age. And Chapter 4 considered the results of blood tests and serum biochemistry and also focused on howler monkeys (n = 20) and capuchin monkeys (n = 21). In general, it was observed that the saimiri is a good comparative model for the study of pelvic disorders in women. In addition, it was possible to validate the DHEAS assay in blood and feces samples from the three studied species, confirmed by the increase in the production of target hormones, and by parallelism and precision tests, with higher concentrations observed in howler monkeys. In the renal evaluation, differences between genders, age, and species were observed, suggesting that the howler monkey has a faster aging mechanism than the capuchin monkey, however, high metabolic demands in the latter. In the hematological and serum biochemistry tests, the effect of species, sex, age, and level of parasitism on several parameters was observed. Therefore, the PNH, especially the platyrrhines, are animals of great importance in biomedical and comparative morphophysiology studies. The differences found in the biomarkers of these species may indicate how they adapt to habitat and management conditions, and the implications of this for the survival of these animals, in addition to being clinically relevant to assess animal health and the adequacy of the creation of these programs.

BANKING MEMBERS:
Interno - 1305300 - FREDERICO OZANAN BARROS MONTEIRO
Externo à Instituição - MAURICIO TALEBI GOMES - UNIFESP
Externa à Instituição - ALINE AMARAL IMBELONI - IEC
Externo à Instituição - RAFAEL DOS SANTOS DE ANDRADE - UFRA
Externo à Instituição - RODRIGO HIDALGO FRICIELLO TEIXEIRA
Externa à Instituição - TATIANA KUGELMEIER - Fiocruz - RJ
Externo à Instituição - PALOMA ROCHA ARAKAKI HENRIQUES